Anti-glomerular Basement Membrane Glomerulonephritis During the First Trimester of Pregnancy

A 28-year-old woman was admitted during the eighth week of her pregnancy because clinical course consistent with rapid progressive glomerulonephritis (RPGN). Anti-glomerular basement membrane antibody (anti-GBM Ab) and myeloperoxidase anti-neutrophil cytoplasmic (MPO-ANCA) were positive, anti-GBM Ab titer being extremely high. She treated hemodialysis, plasma exchange prednisolone. survived illness; however, neither fetus nor kidney function could be rescued. had human leukocyte antigen (HLA)-DRB1*1502:01, which differs from DRB1*1501 associated GN. When patients have particular symptoms, we should check urine serum creatinine to exclude RPGN, even in cases pregnancy.